20 lipid emulsion12/15/2023 ![]() Intralipid 100 mL, 250 mL, and 500 mL single-dose Flexible Containers Do not pierce the infusion port more than once. ![]() Insert the spike through the infusion port by rotating your wrist slightly until the spike is inserted.Use a 1.2 micron in-line filter for administration.Use infusion sets according to ISO Number 8536-4 with an external spike diameter of 5.5 to 5.7 mm and use a non-vented infusion set or close the air-inlet on a vented set.Immediately before inserting the infusion set, break off the blue infusion port cap.Identify the infusion port ( blue cap with the arrow pointing away from the bag).If the mixture is not white or the emulsion has separated (noted by discoloration, phase separation, or oily droplets), or if particulates and/or leakage are observed, discard the bag. The lipid emulsion should be a homogenous liquid with a milky white appearance. Visually inspect the bag and contents for particulate matter and discoloration prior to administration.Discard the Oxalert sachet (A) and the oxygen absorber (B).Tear the overpouch at notch and pull down.Place the bag on a clean, flat surface.Discard the product if the indicator is black, overpouch is opened or damaged, emulsion color is not white, or seals of bag are broken.Inspect the integrity indicator (Oxalert ®) (A) before removing the overpouch.Use the following instructions to prepare single-dose 100 mL, 250 mL, and 500 mL Flexible containers for administration: Complete the infusion within 12 hours when using a Y-connector and within 24 hours when used as part of an admixture. After connecting the infusion set, start infusion of Intralipid immediately.Intralipid can be infused concurrently into the same vein as dextrose-amino acid solutions (as part of PN) by a Y-connector located near the infusion site flow rates of each solution should be controlled separately by infusion pumps.Do not use infusion sets and lines that contain di-2-ethylhexyl phthalate (DEHP), including infusion sets that contain polyvinyl chloride (PVC) components, because they contain DEHP as a plasticizer.Do not pressurize the flexible bag to increase flow rates, and if administration is controlled by a pumping device, turn off the pump before the bag runs dry.To prevent air embolism, use a non-vented infusion set or close the vent on a vented set and fully evacuate residual gas in the bag prior to administration.Do not connect multiple medications in series. Use a dedicated infusion line without any connections.Use a 1.2 micron in-line filter during administration.Less than 900 mOsm/L may be administered either through a central or peripheral vein.Greater than or equal to 900 mOsm/L must be infused through a central vein.Do not exceed the recommended maximum infusion rate in Table 1.Intralipid is for intravenous infusion into a central or peripheral vein.Patients and caregivers may prepare and administer Intralipid for home use after appropriate training by a trained healthcare provider. Intralipid is prepared and administered by a healthcare provider in the inpatient setting.Hepatic Dose : Use with caution in patients with severe hepatic impairment. Fat emulsion is contraindicated in patients with disturbances of normal fat metabolism such as pathologic hyperlipemia, lipoid nephrosis or acute pancreatitis if accompanied by hyperlipidemia.Įarly adverse reactions: Cyanosis, allergic reactions, dyspnea, hyperlipidemia, hypercoagulability, vomiting, nausea, flushing, headache, increase in temperature, sweating, sleepiness, pain in the chest and back, dizziness, slight pressure over the eyes, and irritation at the site of infusion, and, rarely, thrombocytopenia in neonates.ĭelayed adverse reactions: Hepatomegaly, jaundice due to central lobular cholestasis, leukopenia, thrombocytopenia, splenomegaly, transient increases in liver function tests, and overloading syndrome (fever, leucocytosis, focal seizures, hepatomegaly, splenomegaly and shock). Should make up no more than 60% of the total caloric input to the patient. if no untoward reactions occur, the rate can be changed to permit infusion of 0.5 ml of 20% IV fat emulsion/kg/hour. Infusion rate: Not more than 0.05 ml/minute for the first 10 to 15 minutes.
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